Desipramine, commonly used as a noradrenergic neuroprotectant in 6-OHDA-lesions, leads to local functional changes in the urinary bladder and gastrointestinal tract in healthy rats

Desipramine, commonly used as a noradrenergic neuroprotectant in 6-OHDA-lesions, leads to local functional changes in the urinary bladder and gastrointestinal tract in healthy rats

The 6-hydroxydopamine (6-OHDA) rat model is one of the most common animal models of Parkinson's disease. When experimentally inducing dopaminergic neurodegeneration in the nigrostriatal pathway using 6-OHDA, the noradrenergic reuptake inhibitor desipramine is often systemically injected in orde...

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Bibliographic Details
Main Authors: Maria del Pilar Murillo, Patrik Aronsson, Michael Winder, Thomas Carlsson
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Heliyon
Subjects:
Parkinson's disease
Non-motor symptoms
Urinary bladder detrusor
Colon
Ileum
Gastrointestinal system
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402032315X

Internet

http://www.sciencedirect.com/science/article/pii/S240584402032315X

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