Hydroxyurea Improves Spatial Memory and Cognitive Plasticity in Mice and Has a Mild Effect on These Parameters in a Down Syndrome Mouse Model

Hydroxyurea Improves Spatial Memory and Cognitive Plasticity in Mice and Has a Mild Effect on These Parameters in a Down Syndrome Mouse Model

Down syndrome (DS), a genetic disorder caused by partial or complete triplication of chromosome 21, is the most common genetic cause of intellectual disability. DS mouse models and cell lines display defects in cellular adaptive stress responses including autophagy, unfolded protein response, and mi...

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Bibliographic Details
Main Authors: Rebecca Deering Brose, Alena Savonenko, Benjamin Devenney, Kirby D. Smith, Roger H. Reeves
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Down syndrome
trisomy
hydroxyurea
adaptive stress response
neurodegeneration
nootropic effect
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00096/full

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00096/full

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