PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

Abstract That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson’s disease is a widely appreciated but poorly understood phenomenon. Many vulnerable subpopulations, including dopamine neurons in the substantia nigra pars compacta, have a shared...

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Bibliographic Details
Main Authors: Preston Ge, Valina L. Dawson, Ted M. Dawson
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson disease
Parkin
PINK1
Mitochondria
Mitophagy
Selective vulnerability
Online Access:http://link.springer.com/article/10.1186/s13024-020-00367-7

Internet

http://link.springer.com/article/10.1186/s13024-020-00367-7

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