Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit cognitive and motor deficits, and have delays in...

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Bibliographic Details
Main Authors: Nadine M. Aziz, Faycal Guedj, Jeroen L. A. Pennings, Jose Luis Olmos-Serrano, Ashley Siegel, Tarik F. Haydar, Diana W. Bianchi
Format: Article
Language:English
Published: The Company of Biologists 2018-06-01
Series:Disease Models & Mechanisms
Subjects:
Down syndrome
Ts65Dn
Ts1Cje
Dp(16)1/Yey
Developmental disorders
Lifespan analysis
Brain development
Online Access:http://dmm.biologists.org/content/11/6/dmm031013

Internet

http://dmm.biologists.org/content/11/6/dmm031013

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