A β-Wrapin Targeting the N-Terminus of α-Synuclein Monomers Reduces Fibril-Induced Aggregation in Neurons

A β-Wrapin Targeting the N-Terminus of α-Synuclein Monomers Reduces Fibril-Induced Aggregation in Neurons

Reducing α-synuclein pathology constitutes a plausible strategy against Parkinson’s disease. As we recently demonstrated, the β-wrapin protein AS69 binds an N-terminal region in monomeric α-synuclein, interferes with fibril nucleation, and reduces α-synuclein aggregation in vitro and in a fruit fly...

Full description

Bibliographic Details
Main Authors: Éva M. Szegő, Fabian Boß, Daniel Komnig, Charlott Gärtner, Lennart Höfs, Hamed Shaykhalishahi, Michael M. Wördehoff, Theodora Saridaki, Jörg B. Schulz, Wolfgang Hoyer, Björn H. Falkenburger
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein
pre-formed fibrils
protein aggregation
molecular chaperones
nanobodies
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.696440/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.696440/full

Similar Items