Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline

Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline

Proline utilization A (PutA) is a bifunctional flavoenzyme that catalyzes the two-step oxidation of l-proline to l-glutamate using spatially separated proline dehydrogenase (PRODH) and l-glutamate-γ-semialdehyde dehydrogenase (GSALDH) active sites. Substrate inhibition of the coupled PRODH-GSALDH re...

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Bibliographic Details
Main Authors: David A. Korasick, Travis A. Pemberton, Benjamin W. Arentson, Donald F. Becker, John J. Tanner
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
flavoenzyme
proline dehydrogenase
">l-glutamate-γ-semialdehyde dehydrogenase
substrate inhibition
X-ray crystallography
Online Access:https://www.mdpi.com/1420-3049/23/1/32

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https://www.mdpi.com/1420-3049/23/1/32

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