Connexin 43 Suppresses Tumor Angiogenesis by Down-Regulation of Vascular Endothelial Growth Factor via Hypoxic-Induced Factor-1α

Connexin 43 Suppresses Tumor Angiogenesis by Down-Regulation of Vascular Endothelial Growth Factor via Hypoxic-Induced Factor-1α

Previous work showed that connexin 43 (Cx43) reduced the expression of hypoxic-induced factor-1α (HIF-1α) in astrocytes. HIF-1α is a master transcription factor for angiogenesis in tumor. Angiogenesis is essential for tumor progression. Here, we investigated the role of Cx43 in vascular endothelial...

Full description

Bibliographic Details
Main Authors: Wei-Kuang Wang, Man-Chin Chen, Hon-Fai Leong, Yu-Liang Kuo, Chun-Yu Kuo, Che-Hsin Lee
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:International Journal of Molecular Sciences
Subjects:
connexin 43 (Cx43)
vascular endothelial growth factor (VEGF)
hypoxic-induced factor-1α (HIF-1α)
angiogenesis
Online Access:http://www.mdpi.com/1422-0067/16/1/439

Internet

http://www.mdpi.com/1422-0067/16/1/439

Similar Items