Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR.

Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR.

We studied Mesenchymal Stromal Cells (MSC) effects in experimental Unilateral Ureteral Obstruction (UUO), a fibrogenic renal disease. Rats were divided in 5 groups: sham, UUO, MSC treated-UUO, ACEi treated-UUO, MSC+ACEi treated- UUO. Data were collected at 1, 7, 21 days. UUO induced monocyte renal i...

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Bibliographic Details
Main Authors: Marilena Gregorini, Valeria Corradetti, Chiara Rocca, Eleonora Francesca Pattonieri, Teresa Valsania, Samantha Milanesi, Nicoletta Serpieri, Giulia Bedino, Pasquale Esposito, Carmelo Libetta, Maria Antonietta Avanzini, Melissa Mantelli, Daniela Ingo, Sabrina Peressini, Riccardo Albertini, Antonio Dal Canton, Teresa Rampino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4750962?pdf=render

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http://europepmc.org/articles/PMC4750962?pdf=render

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