Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle Enzymes Are Sensitive Targets of Traumatic Brain Injury Induced Metabolic Derangement

Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle Enzymes Are Sensitive Targets of Traumatic Brain Injury Induced Metabolic Derangement

Using a closed-head impact acceleration model of mild or severe traumatic brain injury (mTBI or sTBI, respectively) in rats, we evaluated the effects of graded head impacts on the gene and protein expressions of pyruvate dehydrogenase (PDH), as well as major enzymes of mitochondrial tricarboxylic ac...

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Bibliographic Details
Main Authors: Giacomo Lazzarino, Angela Maria Amorini, Stefano Signoretti, Giuseppe Musumeci, Giuseppe Lazzarino, Giuseppe Caruso, Francesco Saverio Pastore, Valentina Di Pietro, Barbara Tavazzi, Antonio Belli
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
traumatic brain injury
mitochondrial dysfunction
pyruvate dehydrogenase
tricarboxylic acid cycle
acetyl-coa
concussion
Online Access:https://www.mdpi.com/1422-0067/20/22/5774

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https://www.mdpi.com/1422-0067/20/22/5774

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