Minimal traumatic brain injury causes persistent changes in DNA methylation at BDNF gene promoters in rat amygdala: A possible role in anxiety-like behaviors

Minimal traumatic brain injury causes persistent changes in DNA methylation at BDNF gene promoters in rat amygdala: A possible role in anxiety-like behaviors

Minimal traumatic brain injury (MTBI) often transforms into chronic neuropsychiatric conditions including anxiety, the underlying mechanisms of which are largely unknown. In the present study, we employed the closed-head injury paradigm to induce MTBI in rats and examined whether DNA methylation can...

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Bibliographic Details
Main Authors: Sneha Sagarkar, Tanmayi Bhamburkar, Gajanan Shelkar, Amit Choudhary, Dadasaheb M. Kokare, Amul J. Sakharkar
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Neurobiology of Disease
Subjects:
5-Azacytidine
Amygdala
Anxiety
Brain-derived neurotrophic factor
DNA methylation
Minimal traumatic brain injury
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301444

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http://www.sciencedirect.com/science/article/pii/S0969996117301444

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