Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins

Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins

S-acylation is the post-translational covalent attachment of fatty acids (FA) onto cysteines. Nuskova et al. find that exposure of cells to different FAs affects which FA is used to S-acylate GNAI proteins, thereby altering GNAI function and EGFR pathway activation, linking metabolism to signaling.

Bibliographic Details
Main Authors: Hana Nůsková, Marina V. Serebryakova, Anna Ferrer-Caelles, Timo Sachsenheimer, Christian Lüchtenborg, Aubry K. Miller, Britta Brügger, Larisa V. Kordyukova, Aurelio A. Teleman
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24844-9

Internet

https://doi.org/10.1038/s41467-021-24844-9

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