Anesthetic Propofol Overdose Causes Vascular Hyperpermeability by Reducing Endothelial Glycocalyx and ATP Production

Anesthetic Propofol Overdose Causes Vascular Hyperpermeability by Reducing Endothelial Glycocalyx and ATP Production

Prolonged treatment with a large dose of propofol may cause diffuse cellular cytotoxicity; however, the detailed underlying mechanism remains unclear, particularly in vascular endothelial cells. Previous studies showed that a propofol overdose induces endothelial injury and vascular barrier dysfunct...

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Bibliographic Details
Main Authors: Ming-Chung Lin, Chiou-Feng Lin, Chien-Feng Li, Ding-Ping Sun, Li-Yun Wang, Chung-Hsi Hsing
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:International Journal of Molecular Sciences
Subjects:
propofol
mice
endothelial cells
glycocalyx
vascular permeability
ATP
Online Access:http://www.mdpi.com/1422-0067/16/6/12092

Internet

http://www.mdpi.com/1422-0067/16/6/12092

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