Single-Molecule Force Spectroscopy on the N2A Element of Titin: Effects of Phosphorylation and CARP

Single-Molecule Force Spectroscopy on the N2A Element of Titin: Effects of Phosphorylation and CARP

Titin is a large filamentous protein that forms a sarcomeric myofilament with a molecular spring region that develops force in stretched sarcomeres. The molecular spring has a complex make-up that includes the N2A element. This element largely consists of a 104-residue unique sequence (N2A-Us) flank...

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Bibliographic Details
Main Authors: Thomas Lanzicher, Tiankun Zhou, Chandra Saripalli, Vic Keschrumrus, John E. Smith III, Olga Mayans, Orfeo Sbaizero, Henk Granzier
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
titin
passive stiffness
spring elements
post-translational modification
mechano-signaling
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00173/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00173/full

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