Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage

Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage

Human osteoarthritic cartilage contains not only chondrocytes (OACs), but also mesenchymal stromal cells (OA-MSCs), whose abundance increases during osteoarthritis (OA). However, it is not clear how OA-MSC contributes to OA pathogenesis. Here, we show that aging OA-MSC plays an important role in cel...

Full description

Bibliographic Details
Main Authors: Wenguang Liu, Alexander S. Brodsky, Meng Feng, Yajun Liu, Jing Ding, Chathuraka T. Jayasuriya, Qian Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteoarthritis
mesenchymal stem cell
cell senescence
cartilage
SASP
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.725071/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.725071/full

Similar Items