Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats

Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats

Abstract Background Oligodendrocytes (OLs) death after spinal cord injury (SCI) contributes to demyelination, even leading to a permanent neurological deficit. Besides apoptosis, our previous study demonstrated that OLs underwent receptor-interacting serine-threonine kinase 3(RIP3)/mixed lineage kin...

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Bibliographic Details
Main Authors: Hong Fan, Hai-Bin Tang, Le-Qun Shan, Shi-Chang Liu, Da-Geng Huang, Xun Chen, Zhe Chen, Ming Yang, Xin-Hua Yin, Hao Yang, Ding-Jun Hao
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord injury
Oligodendrocyte
Necroptosis
Macrophages/microglia
Quercetin
Online Access:http://link.springer.com/article/10.1186/s12974-019-1613-2

Internet

http://link.springer.com/article/10.1186/s12974-019-1613-2

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