Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice

Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration. Murine FH (mFH), produced in the same host, is useful for pre-clinical investigations in mouse models of disease....

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Bibliographic Details
Main Authors: Heather Kerr, Andrew P. Herbert, Elisavet Makou, Dariusz Abramczyk, Talat H. Malik, Hannah Lomax-Browne, Yi Yang, Isabel Y. Pappworth, Harriet Denton, Anna Richards, Kevin J. Marchbank, Matthew C. Pickering, Paul N. Barlow
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
complement system
factor H
C3 glomerulonephritis mouse model
therapeutic protein
C3 glomerulonephritis
chaperonin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.681098/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.681098/full

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