Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model

Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model

Abstract Background Neuron-microglia communication plays a crucial role in the motor neurons (MNs) death in amyotrophic lateral sclerosis (ALS). Neurons can express chemokine (C-X3-C motif) ligand 1 (CX3CL1), which mediates microglial activation via interacting with its sole receptor CX3CR1 in micro...

Full description

Bibliographic Details
Main Authors: Jingjing Zhang, Yufei Liu, Xinyao Liu, Song Li, Cheng Cheng, Sheng Chen, Weidong Le
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Translational Neurodegeneration
Subjects:
ALS
CX3CL1/CX3CR1 axis
Microglial activation
SOD1G93A mice
Online Access:http://link.springer.com/article/10.1186/s40035-018-0138-4

Internet

http://link.springer.com/article/10.1186/s40035-018-0138-4

Similar Items