Paroxysmal Discharges in Tissue Slices From Pediatric Epilepsy Surgery Patients: Critical Role of GABAB Receptors in the Generation of Ictal Activity

Paroxysmal Discharges in Tissue Slices From Pediatric Epilepsy Surgery Patients: Critical Role of GABAB Receptors in the Generation of Ictal Activity

In the present study, we characterized the effects of bath application of the proconvulsant drug 4-aminopyridine (4-AP) alone or in combination with GABAA and/or GABAB receptor antagonists, in cortical dysplasia (CD type I and CD type IIa/b), tuberous sclerosis complex (TSC), and non-CD cortical tis...

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Bibliographic Details
Main Authors: Simon Levinson, Conny H. Tran, Joshua Barry, Brett Viker, Michael S. Levine, Harry V. Vinters, Gary W. Mathern, Carlos Cepeda
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
pediatric epilepsy
4-aminopyridine
phaclofen
ictal activity
cortical dysplasia
slices
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00054/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00054/full

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