Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases

Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases

We show here that combining two existing genome wide association studies (GWAS) yields additional biologically relevant information, beyond that obtained by either GWAS separately. We propose Joint GWAS Analysis, a method that compares a pair of GWAS for similarity among the top SNP associations, to...

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Bibliographic Details
Main Authors: Michael J. McGeachie, George L. Clemmer, Jessica Lasky-Su, Amber Dahlin, Benjamin A. Raby, Scott T. Weiss
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Genomics Data
Subjects:
Systems genetics
GWAS
Meta-analysis
Pathway enrichment
Pleiotropy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213596014000166

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http://www.sciencedirect.com/science/article/pii/S2213596014000166

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