Chronic renal failure induces cell death in rat hippocampal CA1 via upregulation of αCaMKII/NR2A synaptic complex and phosphorylated GluR1-containing AMPA receptor cascades

Background: N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propinoic acid (AMPA) receptors bound to postsynaptic density-95 (PSD-95) and α isoform of calcium/calmodulin-dependent protein kinase II (αCaMKII) is fundamentally involved in the regulation of working memory. The...

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Bibliographic Details
Main Authors: Jong Wan Kim, Gyoung Yim Ha, Yong Wook Jung
Format: Article
Language:English
Published: The Korean Society of Nephrology 2014-09-01
Series:Kidney Research and Clinical Practice
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211913214000837