Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis

Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis

Antifolates targeting folate biosynthesis within the shikimate-chorismate-folate metabolic pathway are ideal and selective antimicrobials, since higher eukaryotes lack this pathway and rely on an exogenous source of folate. Resistance to the available antifolates, inhibiting the folate pathway, unde...

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Bibliographic Details
Main Authors: Carmen Sadaka, Edmund Ellsworth, Paul Robert Hansen, Richard Ewin, Peter Damborg, Jeffrey L. Watts
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
antifolate
para-aminobenzoic acid
chorismate
resistance
spirotetronate
antibiotic
sulfonamides
prodrug
analoging
Online Access:http://www.mdpi.com/1420-3049/23/6/1371

Internet

http://www.mdpi.com/1420-3049/23/6/1371

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