Truncation of the Catalytic Domain of the Cylindromatosis Tumor Suppressor Impairs Lung Maturation

Truncation of the Catalytic Domain of the Cylindromatosis Tumor Suppressor Impairs Lung Maturation

Cyld encodes a 956-amino acid deubiquitinating enzyme (CYLD), which is a negative regulator of nuclear factor κB and mitogen-activated protein kinase pathways. Mutations that truncate and inactivate the carboxyl-terminal deubiquitinating domain of CYLD underlie the development of skin appendage tum...

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Bibliographic Details
Main Authors: Eirini Trompouki, Ageliki Tsagaratou, Stylianos K. Kosmidis, Pascal Dollé, Jun Qian, Dimitris L. Kontoyiannis, Wellington V. Cardoso, George Mosialos
Format: Article
Language:English
Published: Elsevier 2009-05-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609800559

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http://www.sciencedirect.com/science/article/pii/S1476558609800559

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