Structural confirmation of sulconazole sulfoxide as the primary degradation product of sulconazole nitrate

Sulconazole has been reported to degrade into sulconazole sulfoxide via sulfur oxidation; however, structural characterization data was lacking and the potential formation of an N-oxide or sulfone could not be excluded. To clarify the degradation pathways and incorporate the impurity profile of sulc...

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Bibliographic Details
Main Authors: Qun Xu, Ashraf Khan, Di Gao, Kristie M. Adams, Fatkhulla Tadjimukhamedov, Shane Tan, John T. Simpson
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Journal of Pharmaceutical Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177917301405