Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways

Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways

IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs. This interaction is dependent on antigen-dependent hex...

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Bibliographic Details
Main Authors: Gina-Maria Lilienthal, Johann Rahmöller, Janina Petry, Yannic C. Bartsch, Alexei Leliavski, Marc Ehlers
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
complement
C1q
IgG4
IgG
IgG hexamer
IgG glycosylation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00958/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00958/full

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