Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

Previously we showed that YAP/TAZ promote not only proliferation but also differentiation of immature Schwann cells (SCs), thereby forming and maintaining the myelin sheath around peripheral axons (Grove et al., 2017). Here we show that YAP/TAZ are required for mature SCs to restore peripheral myeli...

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Bibliographic Details
Main Authors: Matthew Grove, Hyunkyoung Lee, Huaqing Zhao, Young-Jin Son
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
Schwann cell
myelination
peripheral nerve regeneration
Yap
Taz
Krox20
Online Access:https://elifesciences.org/articles/50138

Internet

https://elifesciences.org/articles/50138

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