In vitro cobalt-stimulated hypoxia-inducible factor-1 overexpression does not correlate with cancer risk from cobalt exposure in humans

Chemical-induced pulmonary carcinogenesis in humans is usually a multi-decade process. The average age at diagnosis of lung cancer in cigarette smokers, and mesothelioma in asbestos workers, is approximately 70. The carcinogenic process consists of genetic changes to normal cells usually sequenced a...

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Bibliographic Details
Main Authors: Carr J Smith, Thomas A Perfetti
Format: Article
Language:English
Published: SAGE Publishing 2019-05-01
Series:Toxicology Research and Application
Online Access:https://doi.org/10.1177/2397847319850167