Nucleocapsid promotes localization of HIV-1 gag to uropods that participate in virological synapses between T cells.
T cells adopt a polarized morphology in lymphoid organs, where cell-to-cell transmission of HIV-1 is likely frequent. However, despite the importance of understanding virus spread in vivo, little is known about the HIV-1 life cycle, particularly its late phase, in polarized T cells. Polarized T cell...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-10-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC2965768?pdf=render |