Retinoic Acid Induces Embryonic Stem Cells (ESCs) Transition to 2 Cell-Like State Through a Coordinated Expression of Dux and Duxbl1

Retinoic Acid Induces Embryonic Stem Cells (ESCs) Transition to 2 Cell-Like State Through a Coordinated Expression of Dux and Duxbl1

Embryonic stem cells (ESCs) are derived from inner cell mass (ICM) of the blastocyst. In serum/LIF culture condition, they show variable expression of pluripotency genes that mark cell fluctuation between pluripotency and differentiation metastate. The ESCs subpopulation marked by zygotic genome act...

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Bibliographic Details
Main Authors: Daniela Tagliaferri, Pellegrino Mazzone, Teresa M. R. Noviello, Martina Addeo, Tiziana Angrisano, Luigi Del Vecchio, Feliciano Visconte, Vitalba Ruggieri, Sabino Russi, Antonella Caivano, Irene Cantone, Mario De Felice, Michele Ceccarelli, Luigi Cerulo, Geppino Falco
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
retinoic acid
metastate
ESCs
2-cell like
pluripotency
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00385/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00385/full

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