Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, A Co-Drug of <i>N</i>-Acetyl-Cysteine and Cysteamine

Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, A Co-Drug of <i>N</i>-Acetyl-Cysteine and Cysteamine

I-152 combines two pro-glutathione (GSH) molecules, namely N-acetyl-cysteine (NAC) and cysteamine (MEA), to improve their potency. The co-drug efficiently increases/replenishes GSH levels in vitro and in vivo; little is known about its mechanism of action. Here we demonstrate that I-152 not only sup...

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Bibliographic Details
Main Authors: Rita Crinelli, Carolina Zara, Luca Galluzzi, Gloria Buffi, Chiara Ceccarini, Michael Smietana, Michele Mari, Mauro Magnani, Alessandra Fraternale
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
GSH
Cysteamine
N-acetyl cysteine
KEAP1
NRF2
ATF4
Online Access:https://www.mdpi.com/2076-3921/10/2/175

Internet

https://www.mdpi.com/2076-3921/10/2/175

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