CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences

CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences

Copper, the highly toxic micronutrient, plays two essential roles: it is a catalytic and structural cofactor for Cu-dependent enzymes, and it acts as a secondary messenger. In the cells, copper is imported by CTR1 (high-affinity copper transporter 1), a transmembrane high-affinity copper importer, a...

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Bibliographic Details
Main Authors: Ekaterina Y. Ilyechova, Elisa Bonaldi, Iurii A. Orlov, Ekaterina A. Skomorokhova, Ludmila V. Puchkova, Massimo Broggini
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
copper importers CTR1 and DMT1
CRISPR-Cas9
cisplatin
silver
signaling
cuproenzymes
copper homeodynamics
Online Access:https://www.mdpi.com/2073-4409/8/4/322

Internet

https://www.mdpi.com/2073-4409/8/4/322

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