A monoallelic deletion of the TcCRT gene increases the attenuation of a cultured Trypanosoma cruzi strain, protecting against an in vivo virulent challenge.

A monoallelic deletion of the TcCRT gene increases the attenuation of a cultured Trypanosoma cruzi strain, protecting against an in vivo virulent challenge.

Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite infectivity. In a previous work, we characterized a clonal cell line lacking one TcCR...

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Bibliographic Details
Main Authors: Fernando J Sánchez-Valdéz, Cecilia Pérez Brandán, Galia Ramírez, Alejandro D Uncos, M Paola Zago, Rubén O Cimino, Rubén M Cardozo, Jorge D Marco, Arturo Ferreira, Miguel Ángel Basombrío
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3923724?pdf=render

Internet

http://europepmc.org/articles/PMC3923724?pdf=render

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