Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients.

Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients.

Mutations in CuZn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) and are found in 6% of ALS patients. Non-native and aggregation-prone forms of mutant SOD1s are thought to trigger the disease. Two sets of novel antibodies, raised in rabbits and chicken, against peptides spaced...

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Bibliographic Details
Main Authors: Karin Forsberg, P Andreas Jonsson, Peter M Andersen, Daniel Bergemalm, Karin S Graffmo, Magnus Hultdin, Johan Jacobsson, Roland Rosquist, Stefan L Marklund, Thomas Brännström
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2904380?pdf=render

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http://europepmc.org/articles/PMC2904380?pdf=render

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