Augmenting the antinociceptive effects of nicotinic acetylcholine receptor activity through lynx1 modulation.

Neuronal nicotinic acetylcholine receptors (nAChRs) of the cholinergic system have been linked to antinociception, and therefore could be an alternative target for pain alleviation. nAChR activity has been shown to be regulated by the nicotinic modulator, lynx1, which forms stable complexes with nAC...

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Bibliographic Details
Main Authors: Neel I Nissen, Kristin R Anderson, Huaixing Wang, Hui Sun Lee, Carly Garrison, Samantha A Eichelberger, Kasarah Ackerman, Wonpil Im, Julie M Miwa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6029753?pdf=render