A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

Abstract Background Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 using GSK2586881, a recombinant form of human angiotensin-converting enzym...

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Bibliographic Details
Main Authors: Akram Khan, Cody Benthin, Brian Zeno, Timothy E. Albertson, John Boyd, Jason D. Christie, Richard Hall, Germain Poirier, Juan J. Ronco, Mark Tidswell, Kelly Hardes, William M. Powley, Tracey J. Wright, Sarah K. Siederer, David A. Fairman, David A. Lipson, Andrew I. Bayliffe, Aili L. Lazaar
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Critical Care
Subjects:
Angiotensin-converting enzyme 2
Acute lung injury
Respiratory distress syndrome
Adult
Acute respiratory failure
Renin-angiotensin system
Online Access:http://link.springer.com/article/10.1186/s13054-017-1823-x

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http://link.springer.com/article/10.1186/s13054-017-1823-x

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