Delayed Astrogliosis Associated with Reduced M1 Microglia Activation in Matrix Metalloproteinase 12 Knockout Mice during Theiler’s Murine Encephalomyelitis

Delayed Astrogliosis Associated with Reduced M1 Microglia Activation in Matrix Metalloproteinase 12 Knockout Mice during Theiler’s Murine Encephalomyelitis

Theiler’s murine encephalomyelitis (TME) represents a versatile animal model for studying the pathogenesis of demyelinating diseases such as multiple sclerosis. Hallmarks of TME are demyelination, astrogliosis, as well as inflammation. Previous studies showed that matrix metalloproteinase...

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Bibliographic Details
Main Authors: Florian Hansmann, Ning Zhang, Vanessa Herder, Eva Leitzen, Wolfgang Baumgärtner
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
astrogliosis
chemokine receptor 2
knockout mice
matrix metalloproteinases
microglia phenotype
M1
M2
Theiler’s murine encephalomyelitis
Online Access:https://www.mdpi.com/1422-0067/20/7/1702

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https://www.mdpi.com/1422-0067/20/7/1702

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