Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration

Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration

The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a promising treatment strategy. Here, we characterize cone differentiation in retinas derived from mouse embryonic stem cells (mESCs). Similar to...

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Bibliographic Details
Main Authors: Kamil Kruczek, Anai Gonzalez-Cordero, Debbie Goh, Arifa Naeem, Mindaugas Jonikas, Samuel J.I. Blackford, Magdalena Kloc, Yanai Duran, Anastasios Georgiadis, Robert D. Sampson, Ryea N. Maswood, Alexander J. Smith, Sarah Decembrini, Yvan Arsenijevic, Jane C. Sowden, Rachael A. Pearson, Emma L. West, Robin R. Ali
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Stem Cell Reports
Subjects:
blindness
cell- and tissue-based therapy
mouse embryonic stem cells
retina
retinal cone photoreceptor cells
retinal degeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117301844

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http://www.sciencedirect.com/science/article/pii/S2213671117301844

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