PARP1 deficiency protects against hyperglycemia-induced neointimal hyperplasia by upregulating TFPI2 activity in diabetic mice

PARP1 deficiency protects against hyperglycemia-induced neointimal hyperplasia by upregulating TFPI2 activity in diabetic mice

Diabetes mellitus (DM) promotes neointimal hyperplasia, characterized by dysregulated proliferation and accumulation of vascular smooth muscle cells (VSMCs), leading to occlusive disorders, such as atherosclerosis and stenosis. Poly (ADP-ribose) polymerase 1 (PARP1), reported as a crucial mediator i...

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Bibliographic Details
Main Authors: Zhao-yang Wang, Meng-qi Guo, Qing-ke Cui, Haitao Yuan, Shan-ji Fu, Bin Liu, Fei Xie, Wen Qiao, Jie Cheng, Ying Wang, Ming-xiang Zhang
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Redox Biology
Subjects:
PARP1
Neointimal hyperplasia
Diabetes
TFPI2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002433

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http://www.sciencedirect.com/science/article/pii/S2213231721002433

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