Preimplantation Genetic Testing for a Chinese Family With X-Linked Lymphoproliferative Syndrome Type 1

Preimplantation Genetic Testing for a Chinese Family With X-Linked Lymphoproliferative Syndrome Type 1

BackgroundX-linked lymphoproliferative disease (XLP) is a rare primary immunodeficiency disorder. We performed experiments based on two strategies of preimplantation genetic testing (PGT) for a family with XLP caused by a mutation in SH2D1A (c.191G > A).MethodsFirst, a single-cell polymerase...

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Bibliographic Details
Main Authors: Songchang Chen, Weihui Shi, Yeqing Qian, Liya Wang, Junyu Zhang, Shuyuan Li, Yiyao Chen, Chunxin Chang, Hongjun Fei, Lanlan Zhang, Hefeng Huang, Chenming Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Genetics
Subjects:
X-linked lymphoproliferative disease
preimplantation genetic testing
SH2D1A gene
nested PCR reaction
targeted next generation sequencing
haplotyping analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.550507/full

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https://www.frontiersin.org/articles/10.3389/fgene.2020.550507/full

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