Ultra-High Dose Rate FLASH Irradiation Induced Radio-Resistance of Normal Fibroblast Cells Can Be Enhanced by Hypoxia and Mitochondrial Dysfunction Resulting From Loss of Cytochrome C

Ultra-High Dose Rate FLASH Irradiation Induced Radio-Resistance of Normal Fibroblast Cells Can Be Enhanced by Hypoxia and Mitochondrial Dysfunction Resulting From Loss of Cytochrome C

Ultra-high dose rate FLASH irradiation (FLASH-IR) has got extensive attention since it may provide better protection on normal tissues while maintain tumor killing effect compared with conventional dose rate irradiation. The FLASH-IR induced protection effect on normal tissues is exhibited as radio-...

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Bibliographic Details
Main Authors: Jintao Han, Zhusong Mei, Chunyang Lu, Jing Qian, Yulan Liang, Xiaoyi Sun, Zhuo Pan, Defeng Kong, Shirui Xu, Zhipeng Liu, Ying Gao, Guijun Qi, Yinren Shou, Shiyou Chen, Zhengxuan Cao, Ye Zhao, Chen Lin, Yanying Zhao, Yixing Geng, Jiaer Chen, Xueqing Yan, Wenjun Ma, Gen Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ultra-high dose rate irradiation
FLASH
radio-resistance
cell death
hypoxia
normoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.672929/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.672929/full

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