CD169 Defines Activated CD14+ Monocytes With Enhanced CD8+ T Cell Activation Capacity

CD169 Defines Activated CD14+ Monocytes With Enhanced CD8+ T Cell Activation Capacity

Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or regulating inflammatory responses, but their role in T cell stimulation is not well defined. In inflammatory conditions, monocytes frequently show increased expression of CD169/Siglec-1, a type-I interferon (IFN-I)...

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Main Authors: Alsya J. Affandi, Katarzyna Olesek, Joanna Grabowska, Maarten K. Nijen Twilhaar, Ernesto Rodríguez, Anno Saris, Eline S. Zwart, Esther J. Nossent, Hakan Kalay, Michael de Kok, Geert Kazemier, Johannes Stöckl, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl, Juan J. Garcia-Vallejo, Gert Storm, Yvette van Kooyk, Joke M. M. den Haan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
monocyte
CD169
antigen-presentation
CD8+ T cell
nanovaccine
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.697840/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.697840/full

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