Systematic Analysis of Targets of Pumilio-Mediated mRNA Decay Reveals that PUM1 Repression by DNA Damage Activates Translesion Synthesis

Systematic Analysis of Targets of Pumilio-Mediated mRNA Decay Reveals that PUM1 Repression by DNA Damage Activates Translesion Synthesis

Summary: RNA-binding proteins (RBPs) play a pivotal role in gene expression by modulating the stability of transcripts. However, the identification of degradation target mRNAs of RBPs remains difficult. By the combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs to human...

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Bibliographic Details
Main Authors: Toshimichi Yamada, Naoto Imamachi, Katsutoshi Imamura, Kenzui Taniue, Takeshi Kawamura, Yutaka Suzuki, Masami Nagahama, Nobuyoshi Akimitsu
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
RNA-binding proteins
Pumilio
RNA stability
RNA-seq
RIP-seq
BRIC-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720304423

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http://www.sciencedirect.com/science/article/pii/S2211124720304423

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