Circulating Insulin-Like Growth Factor I Is Involved in the Effect of High Fat Diet on Peripheral Amyloid β Clearance

Circulating Insulin-Like Growth Factor I Is Involved in the Effect of High Fat Diet on Peripheral Amyloid β Clearance

Obesity is a risk factor for Alzheimer’s disease (AD), but underlying mechanisms are not clear. We analyzed peripheral clearance of amyloid β (Aβ) in overweight mice because its systemic elimination may impact brain Aβ load, a major landmark of AD pathology. We also analyzed whether circulating insu...

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Bibliographic Details
Main Authors: Raquel Herrero-Labrador, Angel Trueba-Saiz, Laura Martinez-Rachadell, Ma Estrella Fernandez de Sevilla, Jonathan A. Zegarra-Valdivia, Jaime Pignatelli, Sonia Diaz-Pacheco, Ana M. Fernandez, Ignacio Torres Aleman
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
diet
Aβ clearance
IGF-I
Alzheimer disease
Online Access:https://www.mdpi.com/1422-0067/21/24/9675

Internet

https://www.mdpi.com/1422-0067/21/24/9675

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