Circulating Insulin-Like Growth Factor I Is Involved in the Effect of High Fat Diet on Peripheral Amyloid β Clearance
Obesity is a risk factor for Alzheimer’s disease (AD), but underlying mechanisms are not clear. We analyzed peripheral clearance of amyloid β (Aβ) in overweight mice because its systemic elimination may impact brain Aβ load, a major landmark of AD pathology. We also analyzed whether circulating insu...
Main Authors: | Raquel Herrero-Labrador, Angel Trueba-Saiz, Laura Martinez-Rachadell, Ma Estrella Fernandez de Sevilla, Jonathan A. Zegarra-Valdivia, Jaime Pignatelli, Sonia Diaz-Pacheco, Ana M. Fernandez, Ignacio Torres Aleman |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-12-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/24/9675 |
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