An MST4‐pβ‐CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis

An MST4‐pβ‐CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis

Abstract Elevated Wnt/β‐catenin signaling has been commonly associated with tumorigenesis especially colorectal cancer (CRC). Here, an MST4‐pβ‐cateninThr40 signaling axis essential for intestinal stem cell (ISC) homeostasis and CRC development is uncovered. In response to Wnt3a stimulation, the kina...

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Bibliographic Details
Main Authors: Hui Zhang, Moubin Lin, Chao Dong, Yang Tang, Liwei An, Junyi Ju, Fuping Wen, Fan Chen, Meng Wang, Wenjia Wang, Min Chen, Yun Zhao, Jixi Li, Steven X. Hou, Xinhua Lin, Lulu Hu, Wenbo Bu, Dianqing Wu, Lin Li, Shi Jiao, Zhaocai Zhou
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Advanced Science
Subjects:
cancer stem cells
colorectal cancer
intestinal stem cells
MST4‐pβ‐cateninThr40 signaling axis
targeted therapy
Online Access:https://doi.org/10.1002/advs.202004850

Internet

https://doi.org/10.1002/advs.202004850

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