Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites.
Parasitic flatworms are responsible for serious infectious diseases that affect humans as well as livestock animals in vast regions of the world. Yet, the drug armamentarium available for treatment of these infections is limited: praziquantel is the single drug currently available for 200 million pe...
Main Authors: | Fabiana Ross, Paola Hernández, Williams Porcal, Gloria V López, Hugo Cerecetto, Mercedes González, Tatiana Basika, Carlos Carmona, Martín Fló, Gabriela Maggioli, Mariana Bonilla, Vadim N Gladyshev, Mariana Boiani, Gustavo Salinas |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3335049?pdf=render |
Similar Items
-
Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase.
by: Olena Dobrovolska, et al.
Published: (2012-01-01) -
Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths
by: Salinas Gustavo, et al.
Published: (2010-04-01) -
Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase
by: Justin R. Prigge, et al.
Published: (2017-06-01) -
Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes
by: Stephen J. Jenkins, et al.
Published: (2010-01-01) -
Identification of Peptide Antagonists to Thioredoxin Glutathione Reductase of Schistosoma japonicum
by: Li-Jun Song, et al.
Published: (2018-01-01)