Probing the Effect of Physiological Concentrations of IL-6 on Insulin Secretion by INS-1 832/3 Insulinoma Cells under Diabetic-Like Conditions

Probing the Effect of Physiological Concentrations of IL-6 on Insulin Secretion by INS-1 832/3 Insulinoma Cells under Diabetic-Like Conditions

Exercise improves insulin secretion by pancreatic beta cells (β-cells) in patients with type 2 diabetes, but molecular mechanisms of this effect are yet to be determined. Given that contracting skeletal muscle causes a spike in circulating interleukin-6 (IL-6) levels during exercise, muscle...

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Bibliographic Details
Main Authors: Jonathan Barlow, Steven Carter, Thomas P. J. Solomon
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic beta cell dysfunction
insulin secretion
interleukin-6
type 2 diabetes
exercise
skeletal muscle
electrical pulse stimulation
organ crosstalk
Online Access:http://www.mdpi.com/1422-0067/19/7/1924

Internet

http://www.mdpi.com/1422-0067/19/7/1924

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