De-Ubiquitinating Enzymes USP21 Regulate MAPK1 Expression by Binding to Transcription Factor GATA3 to Regulate Tumor Growth and Cell Stemness of Gastric Cancer

De-Ubiquitinating Enzymes USP21 Regulate MAPK1 Expression by Binding to Transcription Factor GATA3 to Regulate Tumor Growth and Cell Stemness of Gastric Cancer

USP21 is a kind of deubiquitinating enzymes involved in the malignant progression of various cancers, while its role in gastric cancer (GC) and the specific molecular mechanism are still unclear. This study probed into the function of USP21 in vitro and in vivo, and discussed the regulatory mechanis...

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Bibliographic Details
Main Authors: Qingqu Guo, Dike Shi, Lele Lin, Hongbo Li, Yunhai Wei, Baozhong Li, Dan Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
gastric cancer
USP21
GATA3
MAPK1
de-ubiquitination
stemness
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.641981/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.641981/full

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