The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484

The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484

Genetic studies of familial schizophrenia in Finland have observed significant associations with a group of biologically related genes, DISC1, NDE1, NDEL1, PDE4B and PDE4D, the ‘DISC1 network’. Here, we use gene expression and psychoactive medication use data to study their biological consequences a...

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Bibliographic Details
Main Authors: Nicholas J. Bradshaw, Liisa Ukkola-Vuoti, Maiju Pankakoski, Amanda B. Zheutlin, Alfredo Ortega-Alonso, Minna Torniainen-Holm, Vishal Sinha, Sebastian Therman, Tiina Paunio, Jaana Suvisaari, Jouko Lönnqvist, Tyrone D. Cannon, Jari Haukka, William Hennah
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Open Biology
Subjects:
schizophrenia
gene expression
disc1 network
nde1
mir-484
pharmacogenetics
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170153

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170153

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