Molecular and Regulatory Mechanisms of Desensitization and Resensitization of GABA<sub>A</sub> Receptors with a Special Reference to Propofol/Barbiturate

It is known that desensitization of GABA<sub>A</sub> receptor (GABA<sub>A</sub>R)-mediated currents is paradoxically correlated with the slowdown of their deactivation, i.e., resensitization. It has been shown that an upregulation of calcineurin enhances the desensitization o...

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Bibliographic Details
Main Authors: Youngnam Kang, Mitsuru Saito, Hiroki Toyoda
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/2/563