IL-4 and IL-17 Are Required for House Dust Mite-Driven Airway Hyperresponsiveness in Autoimmune Diabetes-Prone Non-Obese Diabetic Mice

IL-4 and IL-17 Are Required for House Dust Mite-Driven Airway Hyperresponsiveness in Autoimmune Diabetes-Prone Non-Obese Diabetic Mice

Allergic asthma is characterized by airway inflammation with a Th2-type cytokine profile, hyper-IgE production, mucus hypersecretion, and airway hyperreactivity (AHR). It is increasingly recognized that asthma is a heterogeneous disease implicating complex immune mechanisms resulting in distinct end...

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Bibliographic Details
Main Authors: Anne-Perrine Foray, Céline Dietrich, Coralie Pecquet, François Machavoine, Lucienne Chatenoud, Maria Leite-de-Moraes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
asthma
NOD mice
IL-17
iNKT cells
IL-4
house dust mite
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.595003/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.595003/full

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